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Understanding Cholangiocarcinoma: Shedding Light on a Rare Battle

What is Cholangiocarcinoma?

Cholangiocarcinoma, a rare cancer affecting around 1,300 Australians annually, targets the gallbladder and bile ducts. To comprehend its impact, let's delve into the intricacies of this less-known adversary.

The Gallbladder and Its Role:

The gallbladder, a small pear-shaped organ nestled in the upper abdomen near the liver, plays a pivotal role in storing bile. Bile, produced by the liver, aids in digesting and absorbing fats in the small intestine. Bile duct cancer disrupts this system, affecting tubes transporting bile from the liver to the small intestine.

Spotting Cholangiocarcinoma:

Early detection is challenging, as cholangiocarcinoma often remains asymptomatic in its initial stages. However, some individuals may observe symptoms such as jaundice, nausea, weakness, weight loss, fevers, abdominal pain, darkened urine, pale bowel movements, and itchy skin.

Survival Challenges:

Survival rates for cholangiocarcinoma are disheartening, with only around 1 in 5 diagnosed individuals surviving beyond five years. Lack of awareness is a key hurdle, impeding funding for crucial clinical research. Research into rare cancers, like cholangiocarcinoma, is further complicated by the difficulty in reaching a sizable patient population.

The i-BOXOFFICE Clinical Trial 


WARPNINE is actively raising funds for the i-BOXOFFICE Clinical Trial – a groundbreaking exploration of NALIRIFOX's safety, tolerability, and feasibility. This potent combination, including nal-Irinotecan, fluorouracil, folinic acid, oxaliplatin, durvalumab, and LSTA1, aims to challenge the status quo and provide new hope for advanced biliary cancer patients.

Challenges in Biliary Cancer Treatment:

Biliary cancer poses unique challenges, often diagnosed late, progressing rapidly, and presenting early metastases. The current standard of care provides only modest benefits, emphasizing the urgency for innovative solutions.

The Trial's Vision:

Through the i-BOXOFFICE trial, the goal is clear: to improve overall survival, enhance outcomes, and elevate the quality of life for patients battling biliary cancer.

Spotting the Signs and Taking Action

If you observe any symptoms or changes in digestion, it's crucial to contact your GP promptly.

Understanding Rare Cancers

In Australia, a cancer is deemed rare if it has fewer than 6 diagnoses per 100,000 people. Other less common GI cancers, like oesophageal cancer, liver cancer, NETs, GIST, small bowel cancer, and anal cancer, share the struggle for recognition and research.

Cholangiocarcinoma(bile duct cancer)
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